Professor Claude Lecomte is Professor of Physics and Crystallography and Vice-President of the International Union of Crystallography (IUCr). He is Emeritus Professor since February 2013 and he has grounded the CNRS–Université de Lorraine CRM2 Laboratory named Cristallographie, Resonance Magnetique et Modelisations, (http://www.crystallography.fr), which he directed from 1995 to 2013.

Professor Lecomte has been honoured with the following distinctions:

2010Laureate of the Prize of the European Crystallographic Association Max Perutz Prize (http://www.ecanews.org/)

1997-2002President of the Association Française de Cristallographie (AFC)

2000-2003President of the European Crystallographic Association

2009-2011Member of the Executive Committee of the IUCr

2012-2014Vice President of the IUCr

Professor Lecomte's research areas of interest are: Advanced crystallography, Electron Density Analysis, Structural Science, Instrumentation, Ultra high resolution Biocrystallography, Molecular Magnetic Materials, Molecular Materials, Phase Transitions, Chemical Bonding, Bond and Intermolecular Interactions.

Title of talk: International Year of Crystallography: The IUCr-UNESCO projects

Opening Session, April 2nd, 13:30

Professor Maria Ondina Figueiredo graduated in Chemical-Industrial Engineering in 1961 at Instituto Superior Técnico (IST), earned a Ph.D in 1980 and aggregated in 1991 in applied geology also at IST. Her professional career began in LNEC (Laboratório Nacional de Engenharia Civil), later joining IICT (Instituto de Investigação Científica Tropical), being Research Coordinator and Director of the Crystallography and Mineralogy Centre, as well as President of the Scientific Council of that institute. Teaching in various institutions such as the IST, FCUL (Faculdade de Ciências da Universidade de Lisboa) and UE (Universidade de Évora), her most lasting collaboration was with FCT-UNL (Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa) being one of the founders of the Materials Science Department (DCM - Departamento de Ciência dos Materiais) and CENIMAT (Centro de Investigação de Materiais), teaching subjects such as Crystallography, Crystal Chemistry and Advanced Laboratory Techniques, as Invited Full Professor (gratuitous). In 2006 transferred to LNEG (Laboratório Nacional de Energia e Geologia) where she worked until retirement in 2008. Till this day continues a most active collaboration with LNEG and the FCT.

Maria Ondina Figueiredo developed her main scientific work in the field of crystallography and crystal chemistry, specializing in techniques such as chemical characterization by X-ray fluorescence spectrometry, structural analysis by X-ray Diffraction and X-ray absorption spectroscopies using synchrotron radiation, being in fact part of the commission for the integration of Portugal at the ESRF (European Synchrotron Radiation Facility). She is the author and co-author on more than 200 publications in national and international scientific magazines with revision in addition to numerous communications in conferences in various points of the globe, having been assigned jointly with José Lima-de-Faria the Gulbenkian Award for Science in 1976 (the first edition of that prize).

Title of talk: CRYSTALS: form, metrics, symmetry, atomistic in the perspective of materials

Opening Session, April 2nd, 13:30

Professor Maria Arménia Carrondo is Professor at Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa where she coordinates the Macromolecular Crystallography Unit and is leader of the Structural Genomics laboratory. She was vice-Rector of the Unversidade Nova de Lisboa between 2007 and2013 and vice-Director of ITQB between 1996 and 2005. Maria Arménia Carrondo was elected EMBO member in 2000, received the European Medal for Bio-Inorganic Chemistry in 2004 and was awarded the “Estímulo à Excelência”  from the Ministério da Ciência, Inovação e Ensino Superior in 2004. She is presently coordinator of the Portuguese participation as an Affiliate Centre in the EU Infrastructure Instruct and representative of ITQB as a partner of the BioStruct-X, a project of translational access and enhancement of integrated Biological Structure determination at synchrotron X-ray facilities. Currently Maria Arménia is member of the Science Advisory Committee of the European Synchrotron Radiation Facility, ESRF in Grenoble, member of the Proposal Review Committee of the Swiss Light Source Synchrotron, member of the ERC Life Sciences Evaluation Panel (LS1) for Advanced Grants, evaluator for the Academy of Finland and Editor of Journal of Biological Inorganic Chemistry. Maria Arménia was Co-Director with Tom Blundell of the Erice course in 2010 “Structure and Function from Macromolecular Crystallography: Organisation in Space and Time” and has organized together with Thomas Schneider the courses BioCrys on “Fundamentals of modern methods in Biocrystallography”, that took  place at ITQB in 2002, 2004, 2006, 2008, 2010 and 2012. Another BioCrys is planned for September 2014.

Title of talk: Structural Biology Contribution to New Advances in Science. The Portuguese Case.

Opening Session, April 2nd, 13:30

After gaining the “agrégation” of chemistry at the “Ecole Normale Supérieure” of Lyon, Marine Cotte obtained her PhD for her research, at the C2RMF (Centre of Research and Restoration of French Museums, UMR171 CNRS), on lead-based cosmetics and pharmaceutical compounds used in Antiquity. During her post-doc at the ESRF (European Synchrotron Radiation Facility), she has enlarged the application of micro X-ray and FTIR spectroscopies to ancient paintings, glasses, plastics... She has now a twofold position: as a CNRS scientist at LAMS (Laboratoire d’Archéologie Moléculaire et Structurale) UMR-8220 (Paris), and as a scientist, at the European Synchrotron Radiation Facility (Grenoble). She is in charge of the ID21 beamline, a beamline dedicated to X-ray and infrared micro-spectroscopy, with various applications in the fields of cultural heritage, biology and environmental sciences as well. She is also head of the X-ray imaging group, a group composed of five beamlines, offering imaging capabilities from centimetric field of view for medical applications, to nanometric probes.

Title of talk: Crystallography in the studies of art and historical artifacts

April 16, 12:00

Professor Noam Adir joined the Schulich Faculty of Chemistry, Technion in Haifa Israel in 1995. There he established the Technion Centre for Macromolecular Structure Research, the first macromolecular crystallography lab in the Technion. His interests include: X-ray crystallographic determination of biologically relevant macromolecular structures – proteins, nucleic acids, and complexes; determination of the structure and function of photosynthetic reaction centers and antennas; energy and electron transfer in biological systems; development of devices for solar energy conversion via direct use of photosynthetic membranes; elucidation of factors leading to protein stability/instability and complex assembly/disassembly; enzymes structure and development of novel inhibitors. He is presently the chairman of the Israel Academy of Science's committee for Synchrotron Radiation and also serves as the Deputy Executive Vice President for Research of the Technion.

Prof. Noam Adir, b. Israel 1957. B. Sc. in Chemistry 1984, Hebrew University in Jerusalem, Israel.

Ph. D. in Biochemistry 1990, Hebrew University in Jerusalem, Israel.

Postdoctoral research 1990-1995, Dept. of Physics, Univ. of California, San Diego, USA.

Joined the Schulich Faculty of Chemistry, Technion – Israel Institute of Technology in 1995.

Email: nadir@tx.technion.ac.il

Title of talk: Don't ever give up: unique solutions to unique problems in macromolecular crystallography

April 30, 12:00

Doctor Margarida Archer got her PhD degree in Biochemistry at ITQB/UNL, in 1999 and, since July 2003, she is Auxiliary Investigator at ITQB and Head of the Membrane Protein Crystallography Laboratory. She is Coordinator of Curricular Units within PhD Programs and Master Courses, since 2012, Coordinator of ITQB seminars (invited speakers within Associated Laboratory ITQB, IBET, IGC, CEDOC, 2010-13), and National delegate of the European Crystallographic Association, ECA, since 2009. Her areas of expertise are Structural Biology, X-ray Crystallography, Membrane Proteins, Disease-related proteins, CDP-alcohol phosphatidyltransferases, Membrane Transporters, Sensor kinases, Sulfur metabolism and Structure-Function relationship. Since 2001 Margarida Archer has been Principal Investigator of 6 research projects funded by FCT (Portuguese Foundation for Science and Technology). She's been participant in Marie Curie Integrated Training Network (2008-2011) and in 2 bilateral agreements (with UK in 2007/8 and Ireland in 2009/10). She has supervised 10 Post-Doc students (3 ongoing), 6 PhD and 2 MSc students. Margarida has been involved in the organization of several national and international meetings and courses, such as the International Masterclass “Structure and function of Membrane Proteins: a multidisciplinary approach”, ITQB (2013) and the BioCrys Courses on “Fundamentals of modern methods in Biocrystallography”, ITQB (since 2004, run every two years). She's co-authored 35 publications in peer reviewed journals and 7 book chapters, and lectured 48 communications and 15 Invited oral presentations at international and national meetings.

Title of talk: The rock road of membrane proteins: from gene to structure

May 14, 12:00

Jorge Figueiras é Professor Auxiliar na Universidade de Lisboa, sendo doutorado em Geologia pela mesma Universidade. A sua actividade docente centra-se em temas de Mineralogia e Recursos Minerais e teve a seu cargo o ensino da Cristalografia no Departamento de Geologia da Faculdade de Ciências da Universidade de Lisboa. A sua investigação desenvolve-se principalmente nos campos da mineralogia, da cristaloquímica e da geoquímica em contexto de prospecção de recursos, sobretudo metálicos. Deve-se-lhe (juntamente com J. C. Waerenborgh) a demonstração de que as espinelas naturais de crómio podem sofrer processos de oxidação total do ferro, análogos à transformação de magnetite em maghemite, sem inversão estrutural nem perca significativa dos catiões originais.

Title of talk: Sistemas cristalográficos: 6, 7 ou infinitos?

June 18, 12:00

Professor Robert Huber was born in 1937 in Munich. He studied chemistry at the Technische Universität München (TUM), where he also completed his Ph.D. and habilitation. Since 1972, he has been a member of the Max-Planck-Gesellschaft and Director at the Max-Planck-Institut für Biochemie until his retirement in 2005. Since 1976, he also serves at the TUM as a Professor. He holds appointments as Guest Professor at the Universität Duisburg-Essen (Germany), the Cardiff University (Great Britain), and the Universidad Autonoma de Barcelona (Spain). He serves as a member of the Board and/or Scientific Advisory Board of a number of pharmaceutical and crop science companies, and he is co-founder of two companies, Proteros and Suppremol, located in Martinsried and offering services for drug discovery and development and for the development of novel therapies for autoimmune diseases, respectively. Huber has made major contributions to the understanding of the structure and function of biological macromolecules. He has studied proteases and their natural and synthetic inhibitors, metalloenzymes (iron, nickel, molybdenum, copper), proteins of the immune system (antibodies and antibody receptors), protein hormones and their receptors, protein kinases,  enzymes of amino acid biosynthesis,  enzymes of cofactor and vitamin biosynthesis and proteins of energy and electron transfer. In addition, he has contributed to the development of instruments for data collection and to methods in protein crystallography, particularly Patterson methods, graphic methods, and refinement, to the use of electron rich metal clusters, and most recently to the methods and instruments for crystal improvement. He has been honoured by numerous honorary doctorates, professorships, memberships in learned societies and awards, including the Otto-Warburg Medal, the Emil von Behring Medal, the Sir Hans Krebs Medal, the The Linus Pauling Medal, Max Tishler Prize and, in 1988, the Nobel Prize for Chemistry together with H. Michel and J. Deisenhofer.

Title of talk: Beauty and Fitness for Purpose: the architecture of proteins, the building blocks of life

June 23, 15:00

A Professora Raquel Gonçalves-Maia é Doutorada e Agregada em Química pela Universidade de Lisboa. Pós-Doutoramento na Universidade de Exeter (Reino Unido). É Professora Catedrática aposentada do Departamento de Química e Bioquímica da Faculdade de Ciências da Universidade de Lisboa.

Desenvolveu actividade de investigação na área da Química-Física, tendo sido coordenadora científica do GERQ - Grupo de Estrutura e Reactividade Química. Dirigiu o Boletim da Sociedade Portuguesa de Química e foi representante nacional da Commission on Chemical Kinetics da IUPAC. Foi membro de várias Comissões de Avaliação e de Direcção/Organização universitárias.

Para além da Química, a Epistemologia, a História da Ciência e a Divulgação Científica têm suscitado o seu interesse. Publicou centenas de artigos, vários livros e capítulos de livros, nas áreas mencionadas, e também alguns contos e romances.

Title of talk: "Dos Raios-X à Estrutura Biomolecular": uma perspectiva histórica

September 17, 12:00

Professor Guenter Schwarz was born in 1970 in Suhl. He studied biology at the University of Szeged (Hungary) and Technical University of Braunschweig (Germany), where he also completed his Ph.D. and habilitation. From 2000-2001 he was a Post-doctoral Research Fellow at the Center for Molecular Medicine and Structural Biology, with Prof. Dr. Schindelin (State University of New York at Stony Brook, USA). In 2005 he got appointed as Associate Professor for Biochemistry at University of Cologne. Since 2009 he is Full Professor for Biochemistry and Vice Chair of the Center for Molecular Medicine Cologne. Since 1995, Professor Schwarz has been honoured with numerous awards, notably the:

-“Novartis-Preis” for therapy-related pharmacological research given by the German society of pharmacology and toxicology (in 2003);

-“Max-von-Laue-Preis” for structural biology given by the German Society of Crystallography (in 2005);

-“Horst-Bickel-Award” for the development of novel therapies in the field of inborn errors in metabolism given by Arbeitsgem. für Pediatrische Stoffwechselstörung (in 2009) and;

-Innovation Award of the State North Rhine Westphalia for the development of a therapy to treat Molybdenum Cofactor deficiency (in 2010).

Title of talk: Molybdenum Biochemistry: from neurodegeneration to synaptogenesis and blood pressure

October 1, 12:00

Doctor João M. Dias is a principal scientist at Heptares Therapeutics, leading the crystallographic work on the Muscarinic M1 receptor to target Alzheimer’s disease and pioneering a structure-based drug discovery approach to GPCRs.

João is an all-round hands-on crystallographer with experience from gene-to-structure with more than 15 years of experience, including 7 years of industrial experience.

João did his Ph.D. in Structural Biology studying enzymes and metalloproteins at the New University of Lisbon with Prof. Maria João Romão and at the Max-Planck Institute for Biochemistry in Munich, working directly with Prof. Robert Huber (Nobel prize of chemistry in 1988 for the determination of the three dimensional structure of a photosynthetic reaction centre together with Hartmut Michel and Johann Deisenhofer). After his PhD, João did a postdoc at Merck-Serono, in Geneva working on the structural genomics pipeline, and solving the structure of complexes of human chemokines with novel chemokine binding proteins. Before joining Heptares, João was a research associate at Scripps, San Diego, where he determined the structure of a novel-neutralizing antibody in complex with the ebolavirus glycoprotein, elucidating the conformational epitope suitable as target for vaccines against ebolavirus.

João has more than 25 papers in peer-reviewed journals and contributed to 17 structures deposited in the Protein Databank.

Title of talk: Revolutionising GPCR crystallography and implications for structure-based drug discovery

October 8, 12:00

Sandra de Macedo Ribeiro graduated in Biochemistry in 1992 at the University of Porto (Portugal). During the final semester, Sandra studied Protein Crystallography at the University of Aarhus (Denmark) with an Erasmus fellowship. Shortly after, Sandra joined Prof. Robert Huber's lab at the Max Planck Institute for Biochemistry (Martinsried, Germany), where she carried out the work in Structural Biology that led to her PhD in Chemistry (Technische Universität München, Germany).

Currently, Sandra de Macedo Ribeiro leads the Protein Crystallography Group and coordinates the Molecular and Cellular Biology Unit of IBMC (Porto, Portugal), where she holds a position as researcher since 2006.

Title of talk: Ser or Leu? The structural basis of a genetic code alteration in Candida albicans

October 15, 12:00

Professor Maria Teresa Duarte got a Chemical Engineering Degree from Instituto Superior Técnico (IST, Lisbon) in 1983 and a PhD in Chemistry in 1989 from the same Institute; she received her Habilitation in Chemistry in 2007 at IST.

She started her professional career at IST in 1980 as Demonstrator, Teaching Assistant (1983-89), Assistant Professor and Associate Professor with tenior (1995-2007). She is presently Associate Professor with habilitation. She has been a Fulbright and Humboldt grantee and a post- doctoral Fellow at the Technische Hochschule Darmstadt   (1994- 95). She has been an invited researcher in different Universities in England, USA, Italy, and France. She has been involved on several Institutional assignments and University Management: She is presently Vice-President of the Scientific Board of IST since January 2007, and was IST delegate to CLUSTER (Leading Universities of Science and Technology), 2005-12. In 2004, she received a prize from the Fundação para a Ciência e Tecnologia,  “Estímulo à Excelência” awarded to those scientists with high scientific productivity. She is member of diverse Scientific Societies and member of different International Commissions. She has coordinated different research Projects, published 5 Book Chapters with International distribution, 1  International Patent and has co-authored more than 200 papers in International Journals with peer review, and has presented more than 250 communications at International Conferences.

Title of talk: Unveiling a new world of pharmaceuticals and bioinspired frameworks

October 29, 12:00

Doctor Sakura Pascarelli received a Laurea in Physics at the University La Sapienza (Rome, Italy) and a PhD degree in Physics at the University Joseph Fourier (Grenoble, France).  She has been involved with synchrotron radiation instrumentation and research for over 20 years. Her research today deals with studies on the correlation between magnetism and structure in compressed matter, using X-ray Absorption Spectroscopy and X-ray Magnetic Linear and Circular Dichroism  She is presently Head of the Electronic Structure and Magnetism Group within the Experiment Division of the ESRF and also scientist in charge of  the x-ray absorption spectroscopy beamlines BM23 and ID24.

Title of talk: Investigating Extreme States of Matter by X-ray Absorption Spectroscopy

November 12, 12:00

Professor João Rocha (b. 1962) is Full Professor of Inorganic and Materials Chemistry at the University of Aveiro, Portugal, since 1999, Member of the European Academy of Sciences and the Lisbon Academy of Sciences, director of CICECO-Aveiro Institute of Materials (400 people). He chairs the Commission on Inorganic and Mineral Structures of the International Union of Crystallography. In 2004, he received the Portuguese Science Foundation prize for Scientific Excellence. He has been on the ERC Starting and Advanced Grants Evaluation panel PE5, and on the editorial boards of the Royal Society of Chemistry Nanoscience and Nanotechnology Book Series, and journals Chemistry-a European Journal, EurJIC and Solid State NMR.

He got his Ph.D. in 1991 from the Department of Chemistry, University of Cambridge, U.K., under the supervision of J. Klinowski, and stayed for one year post-doc in the same group.

He has published some 440 papers (with over 10000 citations, h=50) and 3 patents, and gave over 100 talks at international conferences. Supervised 20 Ph.D. students and 27 post-doctoral workers.

His present research interests encompass light emitting lanthanide-bearing microporous and mesoporous materials, and Metal Organic Frameworks for sensing applications; nanosystems for multimodal (magnetic resonance, optical and thermometry) imaging and small molecules drug delivery; solid-state NMR and X-ray diffraction.

Title of talk: Materials and Crystallography: a personal travel guide

November 26, 12:00

Professor Sir Tom Blundell, FRS, FmedSci, Department of Biochemistry at Cambridge

Tom Blundell researches on molecular and structural biology of growth factors, receptor activation, signal transduction and DNA repair, important in cancer and other diseases. He has published 500 research papers, including 30 in Nature.

He was founding CEO of BBSRC 1991-1996 (Chair from 2009), Chairman of Royal Commission on Environment 1998-2005, Deputy Chair of Institute of Cancer Research since 2008 and President of UK Science Council since 2011.

He has written extensive software for structural bioinformatics and developed new approaches to structure-guided and fragment-based drug discovery. In 1999 he co-founded Astex Therapeutics, an oncology company that has eight drugs in clinical trials and that was sold in 2013 as Astex Pharma to Otsuka for $886 million.

In his academic lab he is focusing on the design of new antimicrobials for tuberculosis funded by FP7 MM4TB and Gates HIT-TB and targeting protein-protein interactions for cancer therapeutics.

Title of talk: Genomes, Crystallography and Drug Discovery: Fighting Resistance in Cancer and Tuberculosis

December 3, 12:00

Doctor Giuseppina Padeletti got her Degree in Chemistry cum laude at the University of Perugia in 1984 where remained till 1986 with a research contract. From 1986 to 1988 she was the Person in charge for the R&D Labs Group of ELETTROCARBONIUM S.p.a., (HOECHST Group), working in the field of coal derived materials for the iron and steel industries. During this period she had stages at the University of Ghent, Belgium (on environmental biotechnologies applied at the treatment of industrial waters) and at University of Newcastle upon Tyne, U.K. (on carbon material science). From 1988 she is at the National Research Council of Italy. In 1992-1993 she was visiting scientist at the Laboratoire Central de Recherches, THOMSON-CSF (now THALES), Orsay, France.

Dr. Padeletti acquired her scientific competences in the field of surface and interface chemistry and physics of innovative materials with high technological impact. Her main expertise is in Materials Science, synthesis, growth and characterization of structural and functional properties of semiconductors, oxidic materials, nanostructured films, and nanoparticles in different matrices, for applications in fields such as Health, Sustainable Development and Cultural Heritage.

From 2006 to 2013 she was the Director of the Institute of Nanostructured Materials of CNR. At present, she is CNR Research Director.

She is author of more than 120 papers on scientific international journals and books, more than 160 presentations at international Conference, among them, many as invited speaker. She is Member of the Executive Committee of the European Materials Research Society (EMRS).

Title of talk: Significant findings on the Italian lustred majolica at Reinassance

June 11, 12:00

Professor Brian Kobilka (Nobel Laureate 2012) is Professor of Medicine at Stanford University School of Medicine, Stanford, CA, USA.

Brian Kobilka earned his M.D., cum laude, from Yale University School of Medicine and worked in research as a postdoctoral fellow under Robert Lefkowitz at Duke University, where he started work on cloning the β2-adrenergic receptor. He was a Howard Hughes Medical Institute (HHMI) investigator from 1987-2003 and moved to Stanford in 1989. Professor Kobilka is best known for his research on the structure and activity of G protein-coupled receptors (GPCRs); in particular, work from Kobilka's laboratory determined the molecular structure of the β2-adrenergic receptor. GPCRs are important targets for pharmaceutical therapeutics, but notoriously difficult to work with in X-ray crystallography. The β2-adrenergic receptor structure was soon followed by the determination of the molecular structure of several other G-protein coupled receptors. Professor Kobilka is the 1994 recipient of the American Society for Pharmacology and Experimental Therapeutics John J. Abel Award in Pharmacology. His GPCR structure work was, in part, supported by the 2004 Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke. He received the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for his work on G protein-coupled receptors.

Title of talk: Structural insights into the dynamic process of G protein coupled receptor signaling

2015 June 5, 15:00


Promoted by

Institutional Support

Professor João Morais Cabral’s (IBMC, Portugal) education and research experience:

1983/87:”Licenciatura” in Biochemistry, Universidade do Porto, Porto, Portugal

1987/88: Research assistant at the Analytical section, Dept. of Chemistry, Universidade do Porto, Porto, Portugal

1988/93: Awarded a Ph.D. degree at the University of Edinburgh, Edinburgh,UK

1994/95: Post-doctoral Fellow with Prof. Robert Liddington at Dana-Farber Cancer Institute/Harvard Univ, Boston, USA.

1996/97: Post-doctoral Research Associate with Prof. Robert Liddington at the Biochemistry Dep, Univ of Leicester, UK

1997/2000: Post-doctoral Research Associate with Prof. Roderick MacKinnon at Rockefeller Univ, New York, USA.

2001-2006: Assistant professor at the Dep of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT

2007-2008: Associate Professor at the Dep of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT

2008-        : Principal Investigator at the Instituto de Biological Molecular e Celular, Porto, Portugal

6 most recent publications:

  1. Mari et al “Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains”.Proc Natl Acad Sci U S A. (2011), 108:20802-7

  2. Marques-Carvalho et al “Crystallization and preliminary X-ray crystallographic characterization of a cyclic nucleotide-binding homology domain from the mouse EAG potassium channel” Acta Crystallogr Sect F Struct Biol Cryst Commun. (2012), 68: 337-339

  3. Harley et al “Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel.” PLoS One (2012), 7(3):e32654.

  4. Marques-Carvalho et al “Structural, biochemical and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel” J Mol Biol. (2012), 423:34-46.

  5. Adaixo et al “Structural properties of PAS domains from the KCNH potassium channels” PLoS One. (2013);8(3):e59265.

  6. Vieira-Pires et al “The structure of the KtrAB potassium transporter” Nature (2013), 496:323-8

Title of talk: A molecular study of a component of the bacterial machinery involved in hyperosmotic adaptation

May 28, 12:00

Professor Zenaide Carvalho Gonçalves da Silva, Bahia, Brazil, 1941.

Geologist, BS degree from University of Bahia, Brazil, 1964. MA from Rice University, Houston, Texas, USA, 1967. PhD from University of Lisbon, Portugal, 1988. “Aggregation” from Nova University, Portugal, 2001.

Professor at University of Bahia, Brazil, 1966, Lecturer at the University of Wisconsin, USA, 1969-70, Professor at University of Lisbon, 1982-96 and Nova University, 1996-2011, both in Portugal. At present, Associated Professor at Nova, retired.

As a non academic activity, geologist at Geological Surveys in Angola, 1970-73 and Brazil, 1975-1982 and Argo Petroleum in Angola, 1973-74.

Researcher at Northwestern University, Evanston, Illinois, USA, 1967-1969 and at BPI Geophysical Laboratory at the University of Witwatersrand, Johannesburg, South Africa (summer 1990).

Areas of interest and activities: Igneous and Metamorphic Petrology and Geochemistry, Rock Alteration, Rocks in Monuments facing alteration due to aggressive environment. Mineral changes in the rock alteration processes.

Reorganization of the Geological Survey (DNPM) Minerals and Rocks Museum in Rio de Janeiro and Manaus, in Brazil, 1982.

Conferences and scientific publications related to the main research areas in several Scientific Journals. Publication in Portugal and Brazil of a book on a specific rock from Portugal, which was taken to Brazil during XVII and XVIII centuries: “OLIOZ PORTUGUÊS, De Lastro de Navio a Arte na Bahia”.

Title of talk: Cristais - um retrato dos elementos nas estruturas dos minerais

December 17, 12:00

Professor Ada Yonath (Nobel Laureate 2009); Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly, Weizmann Institute of Science, Rehovot, Israel

Born in Jerusalem, Dr. Yonath earned her B.Sc (1962) and M.Sc. (1964) degrees at the Hebrew University of Jerusalem. In 1968, she completed her Ph.D. at the Weizmann Institute of Science. She continued postdoctoral studies at Carnegie Mellon University and at the Massachusetts Institute of Technology, where she first learned about protein crystallography. In 1970, she returned to the Weizmann Institute and established what was, for almost a decade, the only protein crystallography laboratory in Israel.

Dr. Ada Yonath is the pioneer of ribosome crystallography. She began this work in the late 1970s, long before most others thought it possible to crystallize such a large, irregular structure. In 1980, she created the first ribosome crystals from thermophilic and halophilic bacteria. Dr. Yonath was also a pioneer in the use of cryocrystallography--flash-freezing crystals--to minimize damage caused by intense X-rays. Dr. Yonath was the first to observe that the ribosome is riddled with internal channels and chambers, including a cavern that hosts translation and a tunnel that protects newly synthesized proteins. These findings remained controversial for nearly a decade until they were confirmed by cryo-electron microscopy.

Dr. Yonath also used controlled heating and an mRNA analog to trigger protein biosynthesis in ribosomal crystals. She then preserved the activated ribosomal crystals using various chemical compounds. In 2000, she published the 3.3 Angstrom structure of the small (30S) ribosomal subunit.

Among many other awards and honors, in 2009, she received the Nobel Prize in Chemistry along with Venkatraman Ramakrishnan and Thomas A. Steitz for her studies on the structure and function of the ribosome, becoming the first Israeli woman to win the Nobel Prize out of ten Israeli Nobel laureates, the first woman from the Middle East to win a Nobel prize in the sciences, and the first woman in 45 years to win the Nobel Prize for Chemistry.

(adapted from http://www.nigms.nih.gov/News/meetings/stetten/pages/yonath.aspx)

Title of talk: Resistance to Antibiotics and Preserving the Microbiome

2015 February 4, 15:00