Full name: Teresa Santos-Silva
Nationality: Portuguese
Institutional address: REQUIMTE-CQFB
Departamento de Quimica, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa
2829-516 Caparica
Portugal
Contact data: Telephone: 00351-212948300 #10940
Fax: 00351-212948550
Email: teresa.sss [at] fct.unl.pt
Academic degrees: 2006, PhD @ Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa

2001, Graduated @ Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa (15/20)

1.   Previous and current scientific and/or professional activities:

 20/06/2010 - 20/11/2010, Maternity leave of absence

Since 01/07/2009, Auxiliary Researcher @ REQUIMTE-CQFB, FCT-UNL

12/05/2008 - 12/11/2008, Maternity leave of absence

01/01/2007 - 30/06/2009, Pos-Doc of Fundação para a Ciência e Tecnologia @ REQUIMTE-CQFB, FCT-UNL

01/05/2003 - 20/06/2003, Internship, under the supervision of Dr.  Françoise Guerlesquin, in the purification and crystallization of Formate Ddehydrogenase enzyme @ CNRS-Marseille

01/01/2002 - 13/12/2006, PhD student @ REQUIMTE-CQFB, FCT-UNL

01/10/2000 - 22/06/2001, Internship supervised by Prof. Isabel Moura, in the purification and characterization of two Cytochromes from Desulfovibrio gigas @ REQUIMTE-CQFB, FCT-UNL

1.   Area of scientific activity:

 X-ray crystallography, structural biochemistry, metalloproteins, protein-ligand interaction.

Domain of specialization:

 X-ray crystallography, structural biochemistry.

Crystallization and structure determination of metalloproteins.

3D structure of protein-COMRs conjugates/adducts.

Present research interests:

 Crystallization, Structure determination and functional studies of:

(1) Molybdenum enzymes – Aldehyde Oxidoreductase, Formate Dehydrogenases, Nitrate Reductase, Moco-binding proteins

(2) Nitric oxide synthases enzymes and interaction with putative radioactive probes;

(3) Serum proteins and oxygen carriers and interaction with carbon monoxide molecules as putative drugs in inflammatory processes.

Other skills/activities:

 Certificado de Aptidão Profissional (CAP), June 2004.
Teacher of professional courses (level IV) at ETGI, of Universidade Católica. Theoretical and practical lessons of Good Laboratory Practices, Org. Chem. and Anal. Chem. from 2005-2007.
Teacher and organizer of the Monografic course of X-ray Crystallography at FCT-UNL in 2004, 2007 and 2010.
Teacher and organizer of the HANDS ON in Proteins and Proteomics course at FCT-UNL in 2008 and 2009.
Teacher of the theoretical and practicals of the subject X-ray Crystallography at FCT-UNL in 2010 - 2012.
Teacher of the practicalc of the subject Fundamentos de Bioquímica Estrutural at FCT-UNL from 2007-2010.
Invited teacher of Bioquímica Estrutural at FCT of Universidade de Coimbra from 2007-2009.
Invited teacher of Bioinformática e Estrutura Molecular at Universidade de Aveiro in 2009.
Invited teacher of Estrutura e Função de Proteínas at Universidade da Beira Interior in 2010.
Invited teacher of Estrutura e Biologia estrutural at Instituto Superior Técnico, UTL, in 2010.

Supervising experience:

 2008-2009 - Supervision of student Vasco Franco in. Supervision of students Filipa Ferreira and Inês Martins with Bolsa de Integração na Investigação.
2009 - Supervision of Bolseiro de Iniciação à Investigação David Rodrigues, Ana Rita Otrelo Cardoso.
2009-2010 - Supervision of student Ana Rita Otrelo Cardoso, internship of Biochemistry.
2010-2011 - Supervision of student Marino Santos, in master’s thesis.
2011-2012 - Supervision of student Ana Rita Otrelo Cardoso, in master’s thesis.
2011-2012 - Supervision of student Hugo Correia, in master’s thesis.
2011- Supervision of student Marino Santos, in PhD program.

Participation in research projects:

 Team member of project POCTI/QUI/57641/2004, "Structural and functional characterization of Nitrate Reductases and Formate Dehydrogenases", with PI Professora Maria João Romão.
Team member of project PTDC/QUI/64733/2006 “Xanthine Oxidase-Related Enzymes: Structure, Function and Specificity”, with PI Professora Maria João Romão.
PI of project PTDC/BIA-PRO/118377/2010 “Mammalian and Bacterial Aldehyde Oxidases: Structure, mechanism and insights into cofactor binding and protein maturation” (funding 163.311,00 €).
PI of project PTDC/QUI-BIQ/117799/2010 “Protein interaction with CO Releasing Molecules (CORM)” (funding 149.744,00 €).
Prizes and awards: 2001 - Second best student of undergraduation course Química Aplicada, FCT-UNL
Publications: T. Santos-Silva, et al, CurrMedChem, (2011), 18(22):3361-6.
T. Santos-Silva, et al, JACS, (2011), 133(5):1192-119.
Teresa Ribeiro and T. Santos-Silva, et al, BBA, (2010), 1804(10):2054-62.
J. Honzíček, T. Santos-Silva, et al, Organomet, (2009), 28, 2871-79.
T. Santos-Silva, et al, JACS (2009), 131, 7990-99.
P. Vidinha, N. M.T. Lourenço, C. Pinheiro, A. R. Brás, T. Carvalho, T. Santos-Silva, et al, Chem Comm (2008), 5842-44.
T. Santos-Silva, et al , J. Mol. Biol. (2007), 370, 659-673.
T. Santos-Silva, et al , J. Biol. Inorg. Chem. (2006), 11, 548-558.
T. Santos-Silva, et al, Acta Crys. (2005), F61, 967-970.
T. Hettmann, R. A. Siddiqui, C. Frey, Teresa Santos-Silva, et al, Biochem Biophys Res Comm (2004) 320, 1211–1219.
T. Santos-Silva, et al, Acta Cryst. (2004) D60, 968-970.
Oral communications Teresa Santos-Silva, “CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II)Dicarbonyl-Lysozyme Complex”, 15th International Conference in Biological Inorganic Chemistry - ICBIC, Vancouver, Canada, August, 2011.

Teresa Santos-Silva, “CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II)Dicarbonyl-Lysozyme Complex”, 3rd International Conference in Drug Discovery and Therapy, Dubai, UAE, February, 2011.